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apalutamide will lessen the extent or result of ethinylestradiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medication which might be CYP3A4 substrates may lead to decreased exposure to these remedies.Usually do not skip tablets even